From the North: Route 30 South to Mayfield (on left)

From the South and East:
 NYS Thruway (90) to  Exit 27 (Amsterdam)
 30 North to Mayfield (on right)   

From the West:
 NYS Thruway (90) to Exit 28 (Fonda-Fultonville)
 30A North  to 30 North (no turnoffs) to Mayfield.